The material extant of the fortifications of Jaffa, the physical markers of memory, narrates the contrasting status and evolution of one of the oldest port towns in Israel: from grandiose to decline, from thriving multicultural neighbourhoods to immigrant communities over time, from town centre to marginalised significance and shifting centralities

Heart failure with reduced ejection fraction Chest of drawers (HFrEF) is the inability of the heart to adequately contract or eject blood.This heart is unable to produce adequate cardiac output to perfuse vital tissues.At a fundamental level, it is known that the cardioprotective pathway of nitric oxide-soluble guanylate cyclase-cyclic guanosine mo

Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-dependent epitopes reported to involve primarily the leucine rich repeat region of the ectodomain (LRD).However, successful crystallization of TSHR residues 22-260 has omitted important extracellular non-LRD residues including the hinge region which connects the